mmbr.asm.orgHome | Microbiology and Molecular Biology Reviews

ASM Antimicrobial Agents and Chemotherapy Applied and Environmental Microbiology Clinical Microbiology Reviews Clinical and Vaccine Immunology EcoSal Plus Eukaryotic Cell Infection and Immunity Journal of Bacteriology Journal of Clinical Microbiology Journal of Microbiology & Biology Education Journal of Virology mBio Microbiology and Molecular Biology Reviews Microbiology Resource Announcements Microbiology Spectrum Molecular and Cellular Biology mSphere mSystems Log in My alerts My CartHome Articles Latest Articles COVID-19 Special Collection Archive For Authors Submit a Manuscript Scope Editorial Policy Submission, Review, & Publication Processes Organization and Format Errata, Author Corrections Illustrations and Tables Nomenclature Abbreviations and Conventions Ethics Resources and Policies About the Journal About MMBR Editor in Chief Editorial Board For Reviewers For the Media For Librarians For Advertisers Alerts RSS FAQ Subscribe Members Institutions ASM Antimicrobial Agents and Chemotherapy Applied and Environmental Microbiology Clinical Microbiology Reviews Clinical and Vaccine Immunology EcoSal Plus Eukaryotic Cell Infection and Immunity Journal of Bacteriology Journal of Clinical Microbiology Journal of Microbiology & Biology Education Journal of Virology mBio Microbiology and Molecular Biology Reviews Microbiology Resource Announcements Microbiology Spectrum Molecular and Cellular Biology mSphere mSystems User menu Log in My alerts My Cart Search Search for this keyword Advanced search Search for this keyword Advanced Search Home Articles Latest Articles COVID-19 Special Collection Archive For Authors Submit a Manuscript Scope Editorial Policy Submission, Review, & Publication Processes Organization and Format Errata, Author Corrections Illustrations and Tables Nomenclature Abbreviations and Conventions Ethics Resources and Policies About the Journal About MMBR Editor in Chief Editorial Board For Reviewers For the Media For Librarians For Advertisers Alerts RSS FAQ Subscribe Members Institutions The Rid Superfamily of Proteins The pap Genetic Switch 1 2 See all articles Latest Articles Free Editorial The ASM Journals Committee Values the Contributions of Black Microbiologists Patrick D. Schloss , Melissa Junior , Rebecca Alvania , Cesar A. Arias , Andreas Baumler , Arturo Casadevall , Corrella Detweiler , Harold Drake , Jack Gilbert , Michael J. Imperiale , Susan Lovett , Stanley Maloy , Alexander J. McAdam , Irene L. G. Newton , Michael J. Sadowsky , Rozanne M. Sandri-Goldin , Thomas J. Silhavy , Peter Tontonoz , Jo-Anne H. Young , Craig E. Cameron , Isaac Cann , A. Oveta Fuller , Ariangela J. Kozik 31 Jul 2020 Review A Thermosensitive, Phase-Variable Epigenetic Switch: pap Revisited It has been more than a decade since the last comprehensive review of the phase-variable uropathogen-associated pyelonephritis-associated pilus ( pap ) genetic switch. Since then, important data have come to light, including additional factors that regulate pap expression, better characterization of H-NS regulation, the structure of the Lrp octamer in complex with pap regulatory DNA, the temperature-insensitive... Mario Zamora , Christine A. Ziegler , Peter L. Freddolino , Alan J. Wolfe 29 Jul 2020 Review RidA Proteins Protect against Metabolic Damage by Reactive Intermediates The Rid (YjgF/YER057c/UK114) protein superfamily was first defined by sequence homology with available protein sequences from bacteria, archaea, and eukaryotes (L. Parsons, N. Bonander, E. Eisenstein, M. Gilson, et al., Biochemistry 42:80–89, 2003, https://doi.org/10.1021/bi020541w ). The archetypal subfamily, RidA (reactive intermediate deaminase A), is found in all domains of life, with... Jessica L. Irons , Kelsey Hodge-Hanson , Diana M. Downs 15 Jul 2020 Review A Comprehensive View of Translesion Synthesis in Escherichia coli The lesion bypass pathway, translesion synthesis (TLS), exists in essentially all organisms and is considered a pathway for postreplicative gap repair and, at the same time, for lesion tolerance. As with the saying a trip is not over until you get back home,” studying TLS only at the site of the lesion is not enough to understand the whole process of TLS. Recently, a genetic study uncovered that polymerase V (Pol V), a poorly expressed... Shingo Fujii , Robert P. Fuchs 17 Jun 2020 Review A Forgotten Episode of Marburg Virus Disease: Belgrade, Yugoslavia, 1967 In 1967, several workers involved in poliomyelitis vaccine development and production fell ill at three different locations in Europe with a severe and often lethal novel disease associated with grivets ( Chlorocebus aethiops ) imported from Uganda. This disease was named Marburg virus disease (MVD) after the West German town of Marburg an der Lahn, where most human... Elizabeta S. Ristanović (Елизабета С. Ристановић) , Nenad S. Kokoškov (Ненад С. Кокошков) , Ian Crozier , Jens H. Kuhn , Ana S. Gligić (Ана С. Глигић) 13 May 2020 Review Gene Expression: the Key to Understanding HIV-1 Infection? Gene expression profiling of the host response to HIV infection has promised to fill the gaps in our knowledge and provide new insights toward vaccine and cure. However, despite 20 years of research, the biggest questions remained unanswered. A literature review identified 62 studies examining gene expression dysregulation in samples from individuals living with HIV. Changes in gene expression were dependent on cell/tissue type, stage... Melinda Judge , Erica Parker , Denise Naniche , Peter Le Souëf 13 May 2020 Review Bioavailability Based on the Gut Microbiota: a New Perspective The substantial discrepancy between the strong effects of functional foods and various drugs, especially traditional Chinese medicines (TCMs), and the poor bioavailability of these substances remains a perplexing problem. Understanding the gut microbiota, which acts as an effective bioreactor in the human intestinal tract, provides an opportunity for the redefinition of bioavailability. Here, we discuss four different pathways... Feng Zhang , Fang He , Li Li , Lichun Guo , Bin Zhang , Shuhuai Yu , Wei Zhao 29 Apr 2020 Review Small-Molecule Acetylation by GCN5-Related N -Acetyltransferases in Bacteria Acetylation is a conserved modification used to regulate a variety of cellular pathways, such as gene expression, protein synthesis, detoxification, and virulence. Acetyltransferase enzymes transfer an acetyl moiety, usually from acetyl coenzyme A (AcCoA), onto a target substrate, thereby modulating activity or stability. Members of the G CN5- N -... Rachel M. Burckhardt , Jorge C. Escalante-Semerena 15 Apr 2020 Review Touching the Surface: Diverse Roles for the Flagellar Membrane in Kinetoplastid Parasites While flagella have been studied extensively as motility organelles, with a focus on internal structures such as the axoneme, more recent research has illuminated the roles of the flagellar surface in a variety of biological processes. Parasitic protists of the order Kinetoplastida, which include trypanosomes and Leishmania species, provide a paradigm for probing the role of flagella in host-microbe interactions and illustrate... Felice D. Kelly , Marco A. Sanchez , Scott M. Landfear 1 Apr 2020 Review CRISPR Tools To Control Gene Expression in Bacteria CRISPR-Cas systems have been engineered as powerful tools to control gene expression in bacteria. The most common strategy relies on the use of Cas effectors modified to bind target DNA without introducing DNA breaks. These effectors can either block the RNA polymerase or recruit it through activation domains. Here, we discuss the mechanistic details of how Cas effectors can modulate gene expression by blocking transcription initiation... Antoine Vigouroux , David Bikard 1 Apr 2020 See all articlesNEW : COVID-19 Research and News from ASM Journals Submit a Manuscript Submit a Manuscript About MMBRDr. Michael J. Buchmeier...